Antidiabetic Activity of Manonjaya Snakefruit Skin Extract with Zebra Fish (Danio rerio) as Animal Model

This research aimed to determine the active fraction and profile of compounds in Manonjaya sSnakefruit skin extract that can be used as antidiabetic activity using zebra fish. was extracted by maceration 70% ethanol then fractionated n-hexane, ethyl acetate methanol. The showed highest yield total phenolic content well strongest α-glucosidase inhibition with an percentage 64.43%. provided most spot inhibitor. act compound is flavonoid from glycosylflavone flavone groups. Antidiabetic fish indicates Snakefruit decrease blood sugar level after induced alloxan. crude group had 54.51% lower than induction 41.70% negative control. Meanwhile, 65.10% 55.27%